14-3-3 protein dependent modulation of ubiquitin ligase Nedd4-2
نویسندگان
چکیده
منابع مشابه
Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting.
Voltage-dependent potassium channels (Kv) go beyond the stabilization of the resting potential and regulate biochemical pathways, regulate intracellular signaling, and detect energy homeostasis. Because targeted deletion and pharmacological block of the Kv1.3 channel protein produce marked changes in metabolism, resistance to diet-induced obesity, and changes in olfactory structure and function...
متن کاملDietary sodium intake regulates the ubiquitin-protein ligase nedd4-2 in the renal collecting system.
The activity of the epithelial sodium (Na(+)) channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN) needs to be tightly regulated to match urinary Na(+) excretion with dietary Na(+) intake. The ubiquitin-protein ligase Nedd4-2, which in vitro interacts with ENaC subunits and reduces ENaC cell surface abundance and activity by ubiquitylation of the channel, may participate in the con...
متن کاملEndothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2.
Epithelial Na+ channels (ENaCs) mediate sodium reabsorption in the cortical collecting duct (CCD), but the regulatory pathways that modulate the activity of these channels are incompletely understood. Here, we observed that endothelin-1 (ET-1) attenuates ENaC activity acutely by reducing the channel's open probability and chronically by decreasing the number of channels in the plasma membrane. ...
متن کاملPhosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP/protein kinase A (PKA)-regulated chloride channel whose phosphorylation controls anion secretion across epithelial cell apical membranes. We examined the hypothesis that cAMP/PKA stimulation regulates CFTR biogenesis posttranslationally, based on predicted 14-3-3 binding motifs within CFTR and forskolin-induced CFTR expression...
متن کاملTranslational regulation of the expression of the ubiquitin E3 ligase Nedd4–1 by mTORC1-dependent signaling
We found recently that mTORC1 regulates the biosynthesis of the ubiquitin E3 ligase Nedd4-1, but not the close homolog Nedd4-2. This regulatory process plays a key role in promoting neurite growth in neurons of the mammalian central nervous system. The molecular mechanism underlying this rather specific regulation likely involves a pyrimidine-rich sequence stretch near the putative transcriptio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica
سال: 2021
ISSN: ['2053-2733']
DOI: https://doi.org/10.1107/s010876732108586x